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KMID : 0352419930120020209
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Keimyung Medical Journal
1993 Volume.12 No. 2 p.209 ~ p.219
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COPBLAM-V Combination Chemotherapy in Advanced, Intermediate Non-Hodgkin's Lymphomas
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Abstract
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Between March 1989 and June 1992, 29 patients with advanced stage, intermdiate-grade non-Hodgkin's lymphoma were treated with a COPBLAM-V regimen including cyclophosphamide, oncovin, prednisolone, bleomycin, adriamycin, procarbazine, Median age
was
45.7
years and 5 patients were 60 years or old. 18 patients (62.1%) achieved a complete response(CR) and 11 patients(37.9%) had a partial response. Of the 18 CRs, 7 patients(38.9%) suffered a relapse. The median survival time was 36.8 months, and
4-year
survival rate was 40.8% and disease free survival for CRs was 55.2% with a median follow-up 18.6 months. Male gender was negatively associated with response rate and age grater than 60 years, female sex, stage III and IV, B symptoms, decreased
lymphocyte count significantly decreased survival rate. But relative dose intensity of drugs did not influence the outcome. Overall toxicity was acceptible with 1 treatment-related death due to sepsis. The incidence of nonfatal infection was
17.2%.
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KEYWORD
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